The ambiguous role of sirtuins in head and neck squamous cell carcinoma
D Ezhilarasan, T Lakshmi, M Subha… - Oral …, 2022 - Wiley Online Library
Oral cancer is one of the most leading cancer responsible for significant morbidity and
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …
Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function
The cytotoxic anti-cancer drugs cisplatin, paclitaxel, doxorubicin, 5-fluorouracil (5-FU), as
well as targeted drugs including imatinib, erlotinib, and nivolumab, play key roles in clinical …
well as targeted drugs including imatinib, erlotinib, and nivolumab, play key roles in clinical …
The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …
several cell functions of cancer cells. Several natural products modulate both oxidative …
[HTML][HTML] SIRT1 and SIRT6: The role in aging-related diseases
Y You, W Liang - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …
Novel 1, 4-dihydropyridines as specific binders and activators of SIRT3 impair cell viability and clonogenicity and downregulate hypoxia-induced targets in cancer …
The mitochondrial SIRT3 modulates several biological pathways such as cancer,
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
The role of resveratrol in mammalian reproduction
R Pasquariello, N Verdile, TAL Brevini, F Gandolfi… - Molecules, 2020 - mdpi.com
Resveratrol is one of the most investigated natural polyphenolic compounds and is
contained in more than 70 types of plants and in red wine. The widespread interest in this …
contained in more than 70 types of plants and in red wine. The widespread interest in this …
Resveratrol's anti-cancer effects through the modulation of tumor glucose metabolism
Simple Summary The prevention and treatment of cancer is an ongoing medical challenge.
In the context of personalized medicine, the well-studied polyphenol resveratrol could …
In the context of personalized medicine, the well-studied polyphenol resveratrol could …
Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers
W Sun, R Liu, X Gao, Z Lin, H Tang, H Cui, E Zhao - Biomarker Research, 2023 - Springer
The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation,
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …
Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
[HTML][HTML] Novel epigenetic therapeutic strategies and targets in cancer
The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …
therapy has typically been established as a result of scientific and technical innovations in …