Trends in peptide drug discovery

M Muttenthaler, GF King, DJ Adams… - Nature reviews Drug …, 2021 - nature.com
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

An allostatic theory of oxytocin

DS Quintana, AJ Guastella - Trends in cognitive sciences, 2020 - cell.com
Oxytocin has garnered considerable interest for its role in social behavior, as well as for the
potential of intranasal administration to treat social difficulties. However, current theoretical …

A systematic review of primary and secondary callous-unemotional traits and psychopathy variants in youth

SG Craig, N Goulter, MM Moretti - Clinical Child and Family Psychology …, 2021 - Springer
Two variants of callous-unemotional (CU) traits and psychopathy have been proposed,
referred to as primary and secondary. Whereas primary variants are thought to be …

Insular cortex mediates approach and avoidance responses to social affective stimuli

MM Rogers-Carter, JA Varela, KB Gribbons… - Nature …, 2018 - nature.com
Social animals detect the affective states of conspecifics and utilize this information to
orchestrate social interactions. In a social affective preference text in which experimental …

Does oxytocin increase trust in humans? A critical review of research

G Nave, C Camerer… - … on Psychological Science, 2015 - journals.sagepub.com
Behavioral neuroscientists have shown that the neuropeptide oxytocin (OT) plays a key role
in social attachment and affiliation in nonhuman mammals. Inspired by this initial research …

The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview

PG Djupesland, JC Messina, RA Mahmoud - Therapeutic delivery, 2014 - Taylor & Francis
The intricate pathophysiology of brain disorders, difficult access to the brain, and the
complexity and high risks and costs of drug development represent major hurdles for …

Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism

T Watanabe, M Kuroda, H Kuwabara, Y Aoki… - Brain, 2015 - academic.oup.com
Autism spectrum disorder is a prevalent neurodevelopmental disorder with no established
pharmacological treatment for its core symptoms. Although previous literature has shown …

Oxytocin promotes social bonding in dogs

T Romero, M Nagasawa, K Mogi… - Proceedings of the …, 2014 - National Acad Sciences
Recent evidence suggests that enduring social bonds have fitness benefits. However, very
little is known about the neural circuitry and neurochemistry underlying the formation and …

Prolactin and oxytocin: potential targets for migraine treatment

AK Szewczyk, S Ulutas, T Aktürk, L Al-Hassany… - The Journal of …, 2023 - Springer
Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism

Y Aoki, N Yahata, T Watanabe, Y Takano, Y Kawakubo… - Brain, 2014 - academic.oup.com
Recent studies have suggested oxytocin's therapeutic effects on deficits in social
communication and interaction in autism spectrum disorder through improvement of emotion …