Introduction The application of DNA framework nucleic acid materials in the biomedical field
has witnessed continual expansion. Among them, tetrahedral framework nucleic acids …

The trans-cleavage activity of CRISPR/Cas12a has been widely used in biosensing.
However, many CRISPR/Cas12a-based biosensors, especially those that work in “on–off …

Breast cancer's immunosuppressive environment hinders effective immunotherapy, but
oncolytic viruses hold promise for addressing this challenge by targeting tumor cells and …

Controllable and sufficient concentrations of therapeutic agents in gene therapy are critical
to achieve satisfactory outcomes. Herein, a Zn2+/Cu2+ bimetallic nano metal–organic …

DNA nanostructures have been widely explored as an encouraging tool for bioanalysis and
cancer therapy due to its structural programmability and good biocompatibility. The …

Gene therapy has emerged as a promising avenue for treating genetic disorders, cancer,
and other diseases by introducing therapeutic genes or modulating gene expression …

RNA-based therapeutics have emerged as a promising approach for the treatment of
various diseases, including cancer, genetic disorders, and infectious diseases. However, the …

框架核酸是一类具有独特物理, 化学和生物特性的纳米组装寡核苷酸. 根据沃森-
克里克碱基配对规则, 可以利用DNA 配对杂交制备出各种形状和大小的DNA 框架 …