The aim of this study is to identify osteoarthritis (OA)-associated differentially methylated
genes in human articular chondrocytes from patients with OA. DNA methylation profiling of …

Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …

Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public
health problem. Osteogenic differentiation is a complex process associated with the …

Objective Osteoarthritis (OA) is the most common form of arthritis and a leading cause of
disability. OA is characterized by articular chondrocyte deterioration, subchondral bone …

The aim of this work was to determine whether miR-455-3p regulates DNA methylation
during chondrogenic differentiation of hMSCs. The expression of miR-455-3p and de novo …

Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic
mechanisms including DNA methylation. Methylation changes may also play a key role in …

Progress in genetic research has delivered important highlights in the last year. One of the
widest impact is the publication of the Encyclopedia of DNA Elements (ENCODE) project …

Aim: We showed previously that E74-like factor 3 (ELF3) protein levels are increased in
osteoarthritic (OA) cartilage, that ELF3 accounts for inflammatory cytokine-driven MMP13 …

The capacity of bone and cartilage to regenerate can be attributed to skeletal stem cells
(SSCs) that reside within the bone marrow (BM). Given SSCs are rare and lack specific …

Osteoarthritis (OA) is a chronic disease that affects articular cartilage, causing its
degeneration. Although OA is one of the most prevalent pathologies globally, there are no …