Background Advanced glycation end products (AGEs) played an important role for the
development of diabetic foot. In the present study we tried to show the mevalonate pathway …

ABSTRACT Aim Wilms' tumour 1 (WT1) is essential for normal podocyte function. Previous
reports have demonstrated that the WT1 promoter is often methylated in cancers, leading to …

Exposure to trichloroethene (TCE), a ubiquitous environmental contaminant, has been
linked to a variety of autoimmune diseases (ADs) including SLE, scleroderma and hepatitis …

JAK/STAT pathway plays a well-known role in macrophage polarization, but other signaling
routes may also be involved. The aim of this study was to identify new signaling pathways …

The skeletal system is crucial for supporting bodily functions, protecting vital organs,
facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which …

Inducible nitric oxide synthase (iNOS) is an enzyme that plays a key role in intracellular
immune response against respiratory infections. Since various species of nonhuman …

Chondrocytes play an essential role in endochondral bone development, which is requisite
for mammalian skeletal development. During endochondral bone development …

Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of
which is currently unknown. Genetic alteration is one of the key contributing factors for OA …

Osteoarthritis is the most common cause of chronic disability in older adults. It is a slowly
progressive degenerative disorder of articular joints that has multiple etiologies with age …

Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …