Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a
multitude of biological activities. Especially in antimalarial and anticancer research …

Background: Styrylquinolines are characteristic fully aromatic compounds with flat, rather
lipophilic structures. The first reports on their synthesis and biological activity were published …

Simultaneous dearomatizing spirannulation of pyridinium salts is still in its infancy. Here, we
present an organized skeletal remodeling of designed pyridinium salts by utilizing an …

Abstract Series of thirty‐two mono‐, di‐and tri‐substituted 8‐hydroxyquinoline‐2‐
carboxanilides were prepared by microwave‐assisted synthesis. The compounds were …

Herein we describe a method to produce 2-haloalkoxy-3-substituted quinolines via the
cyclization of 2-alkynylanilines with TMSCF3 and THF. This synthetic method uses …

A metal-free, regioselective C–H functionalization of heteroaromatic N-oxides has been
developed. The method enables the synthesis of various benzylated and alkynylated N …

Abstracts Objectives The emergence of resistant strain has aggravated the tuberculosis
situation in the world, running out of control and hard to fight. We evaluate forty new …

Herein, the direct C-5 fluoroalkylselenolation of 8-aminoquinolines is described. The Pd-
catalyzed reaction is performed with the in situ generated fluoroalkylselenyl chloride and …

A copper (II)-catalyzed cascade annulation of simple anilines with two molecules of alkyne
esters for the one-pot synthesis of 2, 4-disubstituted quinolines, with exclusive …

Alveolar echinococcosis (AE) is caused by infection with the fox tapeworm E. multilocularis.
The disease affects humans, dogs, captive monkeys, and other mammals, and it is caused …