Viral vector‐based gene therapies in the clinic
Gene therapies are currently one of the most investigated therapeutic modalities in both the
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …
The approved gene therapy drugs worldwide: from 1998 to 2019
CC Ma, ZL Wang, T Xu, ZY He, YQ Wei - Biotechnology advances, 2020 - Elsevier
With the improvement of gene vectors, the rise of chimeric antigen receptor T cell
immunotherapy and breakthroughs in the genome editing technology, gene therapy had …
immunotherapy and breakthroughs in the genome editing technology, gene therapy had …
Recombinant adeno-associated virus gene therapy in light of Luxturna (and Zolgensma and Glybera): where are we, and how did we get here?
The recent market approvals of recombinant adeno-associated virus (rAAV) gene therapies
in Europe and the United States are landmark achievements in the history of modern …
in Europe and the United States are landmark achievements in the history of modern …
Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy
T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
The relationship between chronic inflammation and neoplastic diseases is not fully
understood. The inflammatory microenvironment of a tumor is an intricate network that …
understood. The inflammatory microenvironment of a tumor is an intricate network that …
A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing
CRISPR-Cas9 genome editing has transformed biotechnology and therapeutics. However,
in vivo applications of some Cas9s are hindered by large size (limiting delivery by adeno …
in vivo applications of some Cas9s are hindered by large size (limiting delivery by adeno …
Viral delivery systems for CRISPR
The frontiers of precision medicine have been revolutionized by the development of
Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing …
Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing …
microRNAs in Parkinson's disease: from pathogenesis to novel diagnostic and therapeutic approaches
L Leggio, S Vivarelli, F L'Episcopo, C Tirolo… - International journal of …, 2017 - mdpi.com
Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …
disorder and the second most common neurodegenerative disease overall. PD is …
[HTML][HTML] Non-viral in vitro gene delivery: it is now time to set the bar!
Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene
delivery. Despite the resources poured into the development of ever more effective …
delivery. Despite the resources poured into the development of ever more effective …
Recent advances in stimulus‐responsive nanocarriers for gene therapy
C Yu, L Li, P Hu, Y Yang, W Wei, X Deng… - Advanced …, 2021 - Wiley Online Library
Gene therapy provides a promising strategy for curing monogenetic disorders and complex
diseases. However, there are challenges associated with the use of viral delivery vectors …
diseases. However, there are challenges associated with the use of viral delivery vectors …
Biomolecular ultrasound and sonogenetics
Visualizing and modulating molecular and cellular processes occurring deep within living
organisms is fundamental to our study of basic biology and disease. Currently, the most …
organisms is fundamental to our study of basic biology and disease. Currently, the most …