Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

ABSTRACT Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of
numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a …

Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted,
damaged, or infected cells in multicellular organisms and also in diverse biological …

This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-
associated cell death, and necrosis. The authors discuss the clinical implications of each of …

Superparamagnetic iron oxide nanoparticles (SPION) with appropriate surface chemistry
have been widely used experimentally for numerous in vivo applications such as magnetic …

Caspases are crucial mediators of programmed cell death (apoptosis). Among them,
caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many …

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

Disease progression in cancer is dependent on the complex interaction between the tumor
and the host inflammatory response. There is substantial evidence in advanced cancer that …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …