Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

The emergence and convergence of cancer genomics, targeted therapies, and network
oncology have significantly expanded the landscape of protein–protein interaction (PPI) …

Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

Understanding the functions of proteins requires information about their protein-protein
interactions (PPI). The collective effort of the scientific community generates far more data on …

Heat shock proteins (HSP) are a family of proteins induced in cells exposed to different
insults. This induction of HSPs allows cells to survive stress conditions. Mammalian HSPs …

Abstract Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their
diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ …

Targeted inhibition of the molecular chaperone Hsp90 results in the simultaneous blockade
of multiple oncogenic signaling pathways and has, thus, emerged as an attractive strategy …

In the current study, new thienopyrimidine conjugates bearing 1, 2, 3-triazole core and
different sugar moieties have been designed and synthesized by Cu (I)-catalysed click …