Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …

Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Rapid advancements in cardiac electrophysiology require today's health care scientists and
practitioners to stay up to date with new information both at the bench and at the bedside …

Background—The molecular mechanism of increased background inward rectifier current (I
K1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Aims The present study was designed to decipher molecular mechanisms underlying
nicotine's promoting atrial fibrillation (AF) by inducing atrial structural remodelling. Methods …

Background—Although downregulation of L-type Ca2+ current (I Ca, L) in chronic atrial
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …