Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …
[HTML][HTML] Ion channels in the heart
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
[图书][B] Cardiac electrophysiology: from cell to bedside E-book
DP Zipes, J Jalife, WG Stevenson - 2017 - books.google.com
Rapid advancements in cardiac electrophysiology require today's health care scientists and
practitioners to stay up to date with new information both at the bench and at the bedside …
practitioners to stay up to date with new information both at the bench and at the bedside …
The G Protein–Gated Potassium Current IK,ACh Is Constitutively Active in Patients With Chronic Atrial Fibrillation
Background—The molecular mechanism of increased background inward rectifier current (I
K1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …
K1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …
potential. Some of the K+ channels are primarily responsible for early repolarization …
Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines
H Shan, Y Zhang, Y Lu, Y Zhang, Z Pan… - Cardiovascular …, 2009 - academic.oup.com
Aims The present study was designed to decipher molecular mechanisms underlying
nicotine's promoting atrial fibrillation (AF) by inducing atrial structural remodelling. Methods …
nicotine's promoting atrial fibrillation (AF) by inducing atrial structural remodelling. Methods …
L-Type Ca2+ Current Downregulation in Chronic Human Atrial Fibrillation Is Associated With Increased Activity of Protein Phosphatases
T Christ, P Boknik, S Wohrl, E Wettwer, EM Graf… - Circulation, 2004 - Am Heart Assoc
Background—Although downregulation of L-type Ca2+ current (I Ca, L) in chronic atrial
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …