Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Abstract Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset
Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

Alzheimer's disease (AD) is the most common dementia. It is known that women with one
ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …