There have been extensive research efforts to develop new strategies for bone tissue
engineering. These have mainly focused on vascularization during the development and …

Complications in treatment of large bone defects using bone grafting still remain. Our
understanding of the endogenous bone regeneration cascade has inspired the exploration …

The aim of this study was to develop a 3-D construct carrying an inherent sequential growth
factor delivery system. Poly (lactic acid-co-glycolic acid)(PLGA) nanocapsules loaded with …

Alginates comprise a unique–and at the same time-diverse family of polysaccharides that
allows fabrication of a variety of biomaterials suitable for tissue engineering. This is reflected …

Many cell populations, derived from both adult tissues and embryonic stem cells, show
promise for the treatment of a variety of diseases. Although the major effort in stem cell …

Bone formation is a complex process that requires concerted function of multiple growth
factors. For this, it is essential to design a delivery system with the ability to load multiple …

Although bone is regenerative, its regeneration capacity is limited. For bone defects beyond
a critical size, further intervention is required. As an attractive strategy, bone tissue …

Three-dimensional culture alters cancer cell signaling; however, the underlying mechanisms
and importance of these changes on tumor vascularization remain unclear. A hydrogel …

Treatment of large defects requires the harvest of fresh living bone from the iliac crest.
Harvest of this limited supply of bone is accompanied by extreme pain and morbidity. This …

A promising strategy to accelerate joint implant integration and reduce recovery time and
failure rates is to deliver a combination of certain growth factors to the integration site. There …