[HTML][HTML] Brain renin–angiotensin system at the intersect of physical and cognitive frailty

C Cosarderelioglu, LS Nidadavolu… - Frontiers in …, 2020 - frontiersin.org
The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

[HTML][HTML] Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions

D Ağagündüz, F Gençer Bingöl, E Çelik… - Journal of Translational …, 2022 - Springer
Probiotics have been defined as “living microorganisms that create health benefits in the
host when taken in sufficient amounts. Recent developments in the understanding of the …

How western diet and lifestyle drive the pandemic of obesity and civilization diseases

W Kopp - Diabetes, metabolic syndrome and obesity: targets and …, 2019 - Taylor & Francis
Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

[HTML][HTML] Protective effect of renin-angiotensin system inhibitors on Parkinson's disease: a nationwide cohort study

Y Jo, S Kim, BS Ye, E Lee, YM Yu - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Renin-angiotensin system (RAS) inhibitors have been suggested as protective
agents in Parkinson's disease (PD). However, epidemiological evidence on the association …

[HTML][HTML] Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets

P Kodam, R Sai Swaroop, SS Pradhan… - Scientific reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

[HTML][HTML] The controversial role of 24-S-hydroxycholesterol in Alzheimer's disease

P Gamba, S Giannelli, E Staurenghi, G Testa, B Sottero… - Antioxidants, 2021 - mdpi.com
The development of Alzheimer's disease (AD) is influenced by several events, among which
the dysregulation of cholesterol metabolism in the brain plays a major role. Maintenance of …

Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders

TC Santiago, L Parra, JV Nani… - Journal of …, 2023 - Wiley Online Library
The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …

[HTML][HTML] The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood …

M Ouk, CY Wu, JS Rabin, A Jackson… - Alzheimer's Research & …, 2021 - Springer
Background The antihypertensive angiotensin receptor blockers (ARBs) and angiotensin-
converting enzyme inhibitors (ACE-Is) have similar indications and mechanisms of action …

Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and …

A Carey, S Fossati - Alzheimer's & Dementia, 2023 - Wiley Online Library
This review summarizes recent evidence on how mid‐life hypertension,
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …

The renin angiotensin system as a therapeutic target in traumatic brain injury

S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …