The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

SVD is the leading cause of VCI and is associated with substantial morbidity. Tackling
cardiovascular risk factors is currently the most effective approach to prevent cognitive …

Alzheimer's disease (AD) represents a particular therapeutic challenge because its
aetiology is very complex, with dynamic progression from preclinical to clinical stages …

Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein
cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin …

To maintain energy supply to the brain, a direct energy source called adenosine
triphosphate (ATP) is produced by oxidative phosphorylation and aerobic glycolysis of …

Background-Chronic cerebral hypoperfusion (CCH) is an important pathophysiological
mechanism of vascular cognitive impairment (VCI). The heterogeneous effects of CCH …

Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) and tau, and
subcortical vascular cognitive impairment (SVCI) is characterized by cerebral small vessel …

White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging
markers of cerebral small-vessel disease, which is prevalent in older individuals and closely …

Background Epidemiological data suggests statins could reduce the risk of dementia, and
more specifically, Alzheimer's disease (AD). Pre-clinical data suggests statins reduce the …

The vascular hypothesis used to explain the pathophysiology of Alzheimer's disease (AD)
suggests that a dysfunction of the cerebral microvasculature could be the beginning of …