Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …

Cancer metastasis refers to the sequence of events whereby tumour cells detach from their
primary tissue, invade and migrate to nearby vasculature, intravasate into circulation, survive …

Although anti-angiogenic therapies (AATs) have some effects against multiple malignancies,
they are limited by subsequent tumor vasculogenesis and progression. To investigate the …

Chemotherapy is the preferred treatment for advanced ovarian cancer, but the 5-year
survival rate remains low partly because of the development of drug resistance. Although it …

F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the
PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain …

Antiangiogenic therapy plays a significant role in combined glioma treatment. However, poor
permeability of the blood–tumor barrier (BTB) limits the transport of chemotherapeutic …

The term metastasis is widely used to describe the endpoint of the process by which tumour
cells spread from the primary location to an anatomically distant site. Achieving successful …

The importance of the Hippo-Yes-associated protein 1 (YAP1) pathway in gastric
carcinogenesis and metastasis has attracted considerable research attention; however, the …

As a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much
attention due to its broad regulatory roles under physiological and pathological conditions …

Abstract Type I IFN (IFN‐I) is the body's first line of defense against pathogen infection. IFN‐I
can induce cellular antiviral responses and therefore plays a key role in driving antiviral …