Abstract The Stimulator of Interferon Genes (STING) is predominantly expressed in immune
cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a …

Reinvigorating the antitumor immune response using immune checkpoint inhibitors (ICIs)
has revolutionized the treatment of several malignancies. However, extended use of ICIs …

As the first line of host defense against pathogenic infections, innate immunity plays a key
role in antitumor immunotherapy. The cyclic GMP‐AMP synthase (cGAS)‐stimulator of …

Oncogene-induced senescence (OIS) is characterized by increased expression of the cell
cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling
pathway serves as a pivotal mediator of innate immunity by triggering the secretion of type I …

Innate immunity plays an important role not only during infection but also homeostatic role
during stress conditions. Activation of the immune system including innate immune response …

Aging is accompanied by impaired mitochondrial function and accumulation of senescent
cells. Mitochondrial dysfunction contributes to senescence by increasing the levels of …

Pattern recognition receptors are critical for the sensing of pathogen-associated molecular
patterns or danger-associated molecular patterns and subsequent mounting of innate …

The tumor cells that drive classical Hodgkin lymphoma (cHL), namely, Hodgkin and Reed-
Sternberg (HRS) cells, display hallmark features that include their rareness in contrast with …

BNCT is a high-linear-energy transfer therapy that facilitates tumor-directed radiation
delivery while largely sparing adjacent normal tissues through the biological targeting of …