The serotonergic system forms a diffuse network within the central nervous system and plays
a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain
functions and is critically involved in many neuropsychiatric disorders. Here, we present a …

Abstract Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that
contributes to the regulation of various physiological functions by its actions in the central …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

The beneficial effects of exercise on brain function have been demonstrated in animal
models and in a growing number of clinical studies on humans. There are multiple …

Diverse members of the G protein-coupled receptor (GPCR) superfamily participate in a
variety of physiological functions and are major targets of pharmaceutical drugs. Here we …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Rats and mice are attracted by novel objects. They readily approach novel objects and
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …

Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and
overall brain and mental health. In particular, AE has a potent impact on promoting the …