The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
[HTML][HTML] Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis
Retrotransposons are highly enriched in the animal genome,–. The activation of
retrotransposons can rewrite host DNA information and fundamentally impact host biology …
retrotransposons can rewrite host DNA information and fundamentally impact host biology …
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
R Chamorro González, T Conrad, MC Stöber, R Xu… - Nature Genetics, 2023 - nature.com
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants
Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable
element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic …
element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic …
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is
challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment …
challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment …
[PDF][PDF] The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens
DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …
genome integrity and viability, multiple DNA double-strand break repair pathways function in …
Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor
evolution, but our understanding of ecDNA biology is limited. We determined the distribution …
evolution, but our understanding of ecDNA biology is limited. We determined the distribution …
Extrachromosomal DNA amplification contributes to small cell lung cancer heterogeneity and is associated with worse outcomes
Small-cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. Oncogenic
MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC …
MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC …