The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …

Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …

Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …

Retrotransposons are highly enriched in the animal genome,–. The activation of
retrotransposons can rewrite host DNA information and fundamentally impact host biology …

Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …

Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable
element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic …

Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is
challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment …

DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …

Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor
evolution, but our understanding of ecDNA biology is limited. We determined the distribution …

Small-cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. Oncogenic
MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC …