Currently, adult stem cells are attracting significant interest in regenerative medicine and
tissue engineering. These cells have been isolated from various tissue sources; however, in …

Pancreatic islet cell transplantation is an effective approach to treat type 1 diabetes, however
the shortage of cadaveric donors and limitations due to rejection require alternative …

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extensive fibroinflammatory
microenvironment that accumulates from the onset of disease progression. Cancer …

Mesenchymal stem cells (MSCs) have already made their mark in the young field of
regenerative medicine. Easily derived from many adult tissues, their therapeutic worth has …

Type 1 diabetes mellitus (T1DM) is one of the autoimmune diseases characterized by beta-
cell dysfunction with serious health complications. Br-MSCs represent a novel valid …

Islet cell replacement is considered as the optimal treatment for type I diabetes. However,
the availability of human pancreatic islets for transplantation is limited. Here, we show that …

Vascularization plays a crucial role in transporting and exchanging nutrients and oxygen
between implanted grafts with the host tissue. In the biofabrication of the implanted grafts …

Background In-vitro expansion of functional beta cells from adult human islets is an attractive
approach for generating an abundant source of cells for beta-cell replacement therapy of …

Side population (SP) cells in the adult kidney are proposed to represent a progenitor
population. However, the size, origin, phenotype, and potential of the kidney SP has been …

Background: Diabetes is a chronic metabolic disorder having a global prevalence of nearly
doubled over the last 30 years and has become one of the major health concerns …