The pathophysiology of type 1 diabetes mellitus (T1DM) is largely related to an innate defect
in the immune system culminating in a loss of self-tolerance and destruction of the insulin …

Significant progress has been made in the field of β-cell replacement therapies by islet
transplantation in patients with unstable Type 1 diabetes mellitus (T1DM). Recent clinical …

Severe dry eye syndrome (DES) is a complex disease that is commonly caused by
inflammatory and degenerative changes in the lacrimal gland, and can result in severe pain …

Early-trimester human fetal pancreas is a promising potential source of pancreatic
progenitor cells. However, the ethical controversy associated with the source of these cells …

The regenerative process of the pancreas is of interest because the main pathogenesis of
diabetes mellitus is an inadequate number of insulin-producing β-cells. The functional mass …

If only at a small scale, islet transplantation has successfully addressed what ought to be the
primary endpoint of any cell therapy: the functional replenishment of damaged tissue in …

Mesenchymal stem cells (MSCs) derived from bone marrow, adipose tissue, and most
connective tissues have been recognized as promising sources for cell‐based therapies …

Bone marrow-derived stem cells have the ability to migrate to sites of tissue damage and
participate in tissue regeneration. The number of circulating stem cells has been shown to …

Type 1 and some forms of type 2 diabetes mellitus are caused by deficiency of insulin-
secretory islet β cells. An ideal treatment for these diseases would therefore be to replace β …

Background aims Mesenchymal stromal cells (MSCs) isolated from various tissues are
under investigation as cellular therapeutics in a wide range of diseases. It is appreciated that …