Tumour dissemination in multiple myeloma disease progression and relapse: a potential therapeutic target in high-risk myeloma

MN Zeissig, ACW Zannettino, K Vandyke - Cancers, 2020 - mdpi.com
Simple Summary Like in solid cancers, the process of dissemination is a critical feature of
disease progression in the blood cancer multiple myeloma. At diagnosis, myeloma patients …

Desmoglein‐2 expression is an independent predictor of poor prognosis patients with multiple myeloma

LM Ebert, K Vandyke, MZ Johan… - Molecular …, 2022 - Wiley Online Library
Multiple myeloma (MM) is the second most common haematological malignancy and is an
incurable disease of neoplastic plasma cells (PC). Newly diagnosed MM patients currently …

Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM)

J Du, Z Lin, XH Fu, XR Gu, G Lu, J Hou - Cell Communication and …, 2024 - Springer
Background The incidence of multiple myeloma (MM), a type of blood cancer affecting
monoclonal plasma cells, is rising. Although new drugs and therapies have improved patient …

Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells' Escape from the Bone Marrow Microenvironment

SW Verbruggen, CL Freeman, FE Freeman - Cancers, 2024 - mdpi.com
Simple Summary New treatments have made a big difference in helping people with
multiple myeloma (MM) live longer. In fact, survival rates have almost doubled compared …

Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

SP Hilchey, MG Palshikar, JA Emo, D Li, J Garigen… - BMC immunology, 2020 - Springer
Background Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial
function, and migration. Conditions of low oxygen tension trigger regulatory cascades …

Digital financial inclusion in emerging economies: evidence from Jordan

A Al Khub, M Saeudy, AM Gerged - Journal of Risk and Financial …, 2024 - mdpi.com
This study explores the role of digital financial inclusion in mitigating poverty and bolstering
economic growth, with a special focus on developing nations during the COVID-19 era …

Role of TAM Receptors in Antimalarial Humoral Immune Response

L John, R Vijay - Pathogens, 2024 - mdpi.com
Immune response against malaria and the clearance of Plasmodium parasite relies on
germinal-center-derived B cell responses that are temporally and histologically layered …

Targeted disruption of bone marrow stromal cell-derived Gremlin1 limits multiple myeloma disease progression in vivo

KC Clark, DR Hewett, V Panagopoulos, N Plakhova… - Cancers, 2020 - mdpi.com
In most instances, multiple myeloma (MM) plasma cells (PCs) are reliant on factors made by
cells of the bone marrow (BM) stroma for their survival and growth. To date, the nature and …

Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-β/Smad pathway activation

Y Nakagawa, E Ashihara, H Yao, A Yokota… - Biochemical and …, 2018 - Elsevier
The emergence of new molecular targeting agents has improved the prognosis of patients
with multiple myeloma (MM). However, MM remains incurable because MM stem cells are …

[HTML][HTML] Characterization of the role of Samsn1 loss in multiple myeloma development

NL Friend, DR Hewett, V Panagopoulos… - FASEB …, 2020 - ncbi.nlm.nih.gov
The protein SAMSN1 was recently identified as a putative tumor suppressor in multiple
myeloma, with re‐expression of Samsn1 in the 5TGM1/KaLwRij murine model of myeloma …