Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …

Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

The demands that are imposed on the liver as a result of its function as a metabolic organ
that extracts nutrients and clears gut-derived microbial products from the blood are met by a …

The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Background & Aims The multiple vital functions of the human liver are performed by highly
specialised parenchymal and non-parenchymal cells organised in complex collaborative …

The liver is a central immunological organ. Liver resident macrophages, Kupffer cells (KC),
but also sinusoidal endothelial cells, dendritic cells (DC) and other immune cells are …

Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide.
Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is …

Liver tolerance is manifest as a bias toward immune unresponsiveness, both in the context
of a major histocompatibility complex–mismatched liver transplant and in the context of liver …

In the past 40 years, liver transplantation has evolved from a high-risk procedure to one that
offers high success rates for reversal of liver dysfunction and excellent patient and graft …