In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

Over the past decade, lung cancer treatment has undergone a major paradigm shift. A
greater understanding of lung cancer biology has led to the development of many effective …

Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

T cells play a key role in cell-mediated immunity, and strategies to genetically modify T cells,
including chimeric antigen receptor (CAR) T cell therapy and T cell receptor (TCR) T cell …

Chimeric antigen receptor (CAR)–T cells have shown efficacy in patients with B cell
malignancies. Yet, their application for solid tumors has challenges that include limited …

Chimeric antigen receptor T (CART) cell immunotherapy has been remarkably successful in
treating certain relapsed/refractory hematological cancers. However, CART cell therapy is …

For many cancer types, the immune system plays an essential role in their development and
growth. Based on these rather novel insights, immunotherapeutic strategies have been …

The most common type of lung cancer is adenocarcinoma (ADC), comprising around 40% of
all lung cancer cases. In spite of achievements in understanding the pathogenesis of this …

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Background: Cancer is one of the leading causes of death worldwide. Over the years, a
number of conventional cytotoxic approaches for neoplastic diseases has been developed …