Folate and carcinogenesis: evidence, mechanisms, and implications
YI Kim - The Journal of nutritional biochemistry, 1999 - Elsevier
Folate, a water-soluble B vitamin, has recently garnered much attention because of its
purported role in the pathogenesis of cardiovascular disease, 1–4 neural tube defects, 5–7 …
purported role in the pathogenesis of cardiovascular disease, 1–4 neural tube defects, 5–7 …
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression
CQ Zhao, MR Young, BA Diwan… - Proceedings of the …, 1997 - National Acad Sciences
Inorganic arsenic, a human carcinogen, is enzymatically methylated for detoxication,
consuming S-adenosyl-methionine (SAM) in the process. The fact that DNA …
consuming S-adenosyl-methionine (SAM) in the process. The fact that DNA …
DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling
DNA methylation is a major epigenetic factor that has been postulated to regulate cell
lineage differentiation. We report here that conditional gene deletion of the maintenance …
lineage differentiation. We report here that conditional gene deletion of the maintenance …
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal
The mouse insulin-like growth factor type 2 receptor (Igf2r) is imprinted and expressed
exclusively from the maternally inherited chromosome. To investigate whether methylation …
exclusively from the maternally inherited chromosome. To investigate whether methylation …
Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis
Background Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype
of T cells that can recognize and destroy tumor specifically. Understanding the regulatory …
of T cells that can recognize and destroy tumor specifically. Understanding the regulatory …
Eukaryotic DNA methylation as an evolutionary device
V Colot, JL Rossignol - Bioessays, 1999 - Wiley Online Library
DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …
widespread among protists, plants, fungi and animals. It is however absent in some species …
Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS study
LJ Van Der Knaap, H Riese, JJ Hudziak… - Translational …, 2014 - nature.com
Stress early in life is a known risk factor for the development of affective disorders later in life.
Epigenetic mechanisms, such as DNA methylation, may have an important role in mediating …
Epigenetic mechanisms, such as DNA methylation, may have an important role in mediating …
[HTML][HTML] Folate status: effects on pathways of colorectal carcinogenesis
Many epidemiologic, animal and human studies suggest that folate status modulates
carcinogenesis. Although these observations have been made in a number of tissues, the …
carcinogenesis. Although these observations have been made in a number of tissues, the …
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2′-deoxycytidine
J Weber, M Salgaller, D Samid, B Johnson, M Herlyn… - Cancer research, 1994 - AACR
MAGE-1 is a gene that encodes an antigen on a melanoma cell line that is recognized by
cytolytic T-cells. We have used a reverse transcription-polymerase chain reaction assay to …
cytolytic T-cells. We have used a reverse transcription-polymerase chain reaction assay to …
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
Abstract Objective Scleroderma (systemic sclerosis; SSc) is an autoimmune disease
characterized by vasculopathy and widespread organ fibrosis. Altered fibroblast function …
characterized by vasculopathy and widespread organ fibrosis. Altered fibroblast function …