DNA methylation: A molecular lock Page 1 Dispatch R305 DNA methylation: A molecular lock
Zahava Siegfried and Howard Cedar In mammals, the promoters of expressed genes are …

We have purified GST-fused recombinant mouse Dnmt3a and three isoforms of mouse
Dnmt3b to near homogeneity. Dnmt3b3, an isoform of Dnmt3b, did not have DNA …

Progressive fibrosis of the skin and of various internal organs, notably, the lungs, heart and
gastrointestinal tract, is the pathologic hallmark of systemic sclerosis (SSc)(for reviews see …

DNA cytosine methylation represents an intrinsic modification signal of the genome that
plays important roles in heritable gene silencing, heterochromatin formation and certain …

The HOM‐MEL‐40 antigen which is encoded by the SSX‐2 gene was originally detected as
a tumor antigen recognized by autologous IgG antibodies in a melanoma patient …

The first crucial step in the developmental program occurs during pre-implantation, the time
after the oocyte has been fertilized and before the embryo implants in the uterus. This period …

DNA methylation is a biochemical process where a DNA base, usually cytosine, is
enzymatically methylated at the 5-carbon position. An epigenetic modification associated …

The fragile-X syndrome of mental retardation is associated with an expansion in the number
of CGG repeats present in the FMR1 gene. The repeat region is within sequences …

Drug resistance, either intrinsic or acquired, represents a major hurdle to achieving optimal
therapeutic outcomes during cancer treatment. In addition to acquisition of resistance …

Being sessile in nature, plants cannot overlook the incursion of unfavorable environmental
conditions, including heat and drought. Heat and drought severely affect plant growth …