The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges
worldwide due to their high morbidity and mortality and limitations in clinical treatment …

The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

Major depression represents a complex and prevalent psychological disease that is
characterized by persistent depressed mood, impaired cognitive function and complicated …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain
injury and neurological impairment. Previous work confirmed the involvement of the …

The basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix
(ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial …

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between
circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly …

Ischemic stroke is a leading cause of mortality and disability. Diabetes mellitus,
characterized by hyperglycemia, is a common concomitant disease of ischemic stroke …

Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist's toolkit. Microglial morphological phenomics can be conducted …