The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

Dysregulation of autophagy and circular RNAs (circRNAs) are involved in the pancreatic
cancer (PC) progression. However, the regulatory network between circRNAs, autophagy …

Abstract A two-dimensional (2D) cell culture-based model is widely applied to study
tumorigenic mechanisms and drug screening. However, it cannot authentically simulate the …

Simple Summary This review article is a summary of the current state of knowledge
regarding the genetics of pancreatic cancer and a presentation of possible treatment options …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Vaccine-based cancer immunotherapy has demonstrated a significant potential for cancer
treatment in clinics. Although the efficiencies of vaccines are limited, they can be enhanced …

类器官技术的发展为更接近机体细胞组成和病理生理特征的癌症模型开辟了新途径.
患者来源的肿瘤类器官在多次传代后仍能维持原有肿瘤的组织病理学及遗传表型特征 …

Long noncoding RNAs (lncRNAs) are a series of RNA molecules without ability to code
proteins. LncRNAs have emerged as significant players in almost all aspects of gene …

Background Single-cell sequencing (SCS) technologies enable analysis of gene structure
and expression data at single-cell resolution. However, SCS analysis in pancreatic cancer …