Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …

Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

In this article, the authors posit that, because osteoarthritis (OA) involves all of the tissues of
the synovial joint, the emphasis on the loss of cartilage, in particular, is misguided. In …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

The repair of articular cartilage defects remains a significant challenge in orthopedic
medicine. Hydrogels, three-dimensional polymer networks swollen in water, offer a unique …

Osteoarthritis (OA) is a prevalent disease of most mammalian species and is a significant
cause of welfare and economic morbidity in affected individuals and populations. In vitro …

Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …