The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR)
are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A …

CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is
known about the effector function of Th cells in combating pathogens and promoting …

The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune
system. When the TCR engages a peptide bound to the restricting major histocompatibility …

Cholesterol molecules specifically bind to the resting αβTCR to inhibit cytoplasmic CD3ζ
ITAM phosphorylation through sequestering the TCR-CD3 complex in an inactive …

Signaling through the T cell receptor (TCR) controls adaptive immune responses. Antigen
binding to TCRαβ transmits signals through the plasma membrane to induce …

CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …

T cell memory plays a critical role in our protection against pathogens and tumors. The
antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that …

Single-molecule localization microscopy (SMLM) has the potential to quantify the diversity in
spatial arrangements of molecules in intact cells. However, this requires that the single …

The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell
fate decisions. Yet how it relays ligand-specific information across the cell membrane for …