Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it
has recently been understood as a low-grade chronic inflammatory process that could …

Osteochondral injury is a common and frequent orthopedic disease that can lead to more
serious degenerative joint disease. Tissue engineering is a promising modality for …

Background Intra-articular injection of mesenchymal stromal cells (MSCs) with
immunomodulatory features and their paracrine secretion of regenerative factors proposed a …

Osteoarthritis (OA) is a serious chronic and degenerative disease that increasingly occurs in
the aged population. Its current clinical treatments are limited to symptom relief and cannot …

Despite great efforts and achievement of nanomaterials in immune-associated diseases, the
selection of appropriate nanomaterials and preparation technology remain some challenges …

Background Osteoarthritis (OA) is an age-related joint disease characterized by progressive
cartilage loss. Synovial mesenchymal stem cells (MSCs) are anticipated as a cell source for …

Despite the uniform selection criteria for the isolation of human mesenchymal stem cells
(MSCs), considerable heterogeneity exists which reflects the distinct tissue origins and …

The collagen-mimetic peptide GFOGER possesses the chondrogenic potential and has
been used as a cell adhesion peptide or chondrogenic inducer. Here, we prepared an …

Potency is one of the critical quality attributes of biological medicinal products, defining their
biological activity. Potency testing is expected to reflect the Mechanism of Action (MoA) of …