Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …

Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing
autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor …

Background & Aims Exclusive enteral nutrition (EEN) is used to treat pediatric Crohn's
disease (CD), but therapeutic benefits are variable, and EEN can lead to microbial …

The microbiome exerts considerable control over immune homeostasis and influences
susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory …

Cancer immunotherapy is rapidly changing the paradigm of cancer care and treatment by
evoking host immunity to kill cancer cells. As clinical approval of checkpoint inhibitors (eg …

Inflammatory bowel disease (IBD) can progress into colitis-associated colorectal cancer
(CAC) through the inflammation-cancer sequence. Although the mechanism of …

The thymus produces self‐limiting and self‐tolerant T cells through the interaction between
thymocytes and thymus epithelial cells (TECs), thereby generating central immune …

Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by
decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of …

Endometriosis is a gynecological condition that is associated with chronic pelvic
inflammation, pain, and infertility. Although substantial evidence supports that …