[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Inflammaging and osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
[HTML][HTML] Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
[HTML][HTML] The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review
K Sun, J Luo, J Guo, X Yao, X Jing, F Guo - Osteoarthritis and cartilage, 2020 - Elsevier
Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …
Radical-scavenging and subchondral bone-regenerating nanomedicine for osteoarthritis treatment
H Lu, J Wei, K Liu, Z Li, T Xu, D Yang, Q Gao, H Xiang… - ACS …, 2023 - ACS Publications
Osteoarthritis (OA) is characterized by cartilage degradation and subchondral bone
remodeling. However, most available studies focus on either cartilage degradation or …
remodeling. However, most available studies focus on either cartilage degradation or …
Inflammation and epigenetic regulation in osteoarthritis
Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …
recognized that there is a major inflammatory component to this disease. In addition to …
Causal factors for knee, hip, and hand osteoarthritis: a Mendelian randomization study in the UK Biobank
T Funck‐Brentano, M Nethander… - Arthritis & …, 2019 - Wiley Online Library
Objective There is no curative treatment for osteoarthritis (OA), which is the most common
form of arthritis. This study was undertaken to identify causal risk factors of knee, hip, and …
form of arthritis. This study was undertaken to identify causal risk factors of knee, hip, and …
[HTML][HTML] Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …
Innovative tissue‐engineered strategies for osteochondral defect repair and regeneration: current progress and challenges
L Zhou, VO Gjvm, J Malda, MJ Stoddart… - Advanced …, 2020 - Wiley Online Library
Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not
completely curative, and thus enormously unfulfilled challenges. With the in‐depth studies of …
completely curative, and thus enormously unfulfilled challenges. With the in‐depth studies of …
[HTML][HTML] Noggin inhibits IL-1β and BMP-2 expression, and attenuates cartilage degeneration and subchondral bone destruction in experimental osteoarthritis
Osteoarthritis (OA) is a chronic inflammatory and progressive joint disease that results in
cartilage degradation and subchondral bone remodeling. The proinflammatory cytokine …
cartilage degradation and subchondral bone remodeling. The proinflammatory cytokine …