IL-6, IL-8, IP-10, MCP-1 and G-CSF are significantly increased in cerebrospinal fluid but not in sera of patients with central neuropsychiatric lupus erythematosus

T Yoshio, H Okamoto, K Kurasawa, Y Dei… - Lupus, 2016 - journals.sagepub.com
Objective To determine whether the intrathecal concentrations of cytokines/chemokines are
associated with, or influenced by, serum concentrations in patients with central …

Фармакология сверхмалых доз антител к эндогенным регуляторам функций

О Эпштейн, МБ Штарк, АМ Дыгай, СА Сергеева… - 2005 - elibrary.ru
В монографии представлены сведения о фармакологической активности и механизмах
действия препаратов на основе сверхмалых доз антител к эндогенным регуляторам …

Granulocyte colony-stimulating factor increases expression of adhesion receptors on endothelial cells through activation of p38 MAPK

B Fusté, R Mazzara, G Escolar, A Merino… - …, 2004 - haematologica.org
BACKGROUND AND OBJECTIVES: Granulocyte colony-stimulating factor (G-CSF) is
specific for the granulocytic cell line, although receptors for this cytokine have been found in …

Modelling human granulopoiesis under poly-chemotherapy with G-CSF support

M Scholz, C Engel, M Loeffler - Journal of mathematical biology, 2005 - Springer
Cytotoxic drugs administered in polychemotherapy cause a characteristic neutropenic
period depending on the schedule of the drugs, which can partly be prevented by G-CSF …

Merging concepts-coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

A Krinner, I Roeder, M Loeffler, M Scholz - BMC systems biology, 2013 - Springer
Background Hematopoiesis is a complex process involving different cell types and feedback
mechanisms mediated by cytokines. This complexity stimulated various models with different …

Role of NF-κB in endotoxemia-induced alterations of lung neutrophil apoptosis

JG Kupfner, JJ Arcaroli, HK Yum, SG Nadler… - The Journal of …, 2001 - journals.aai.org
Acute lung injury is frequently associated with endotoxemia and is characterized by the
accumulation in the lungs of large numbers of neutrophils activated to produce …

Outcome of extremely low birth weight infants with leukemoid reaction

R Hsiao, SA Omar - Pediatrics, 2005 - publications.aap.org
Background. Leukemoid reaction (LR) is defined as an absolute neutrophil count (ANC) of>
30× 103/mm3. No previous study has systemically examined the clinical and prognostic …

Нанотехнологии в фармакологии

АМ Дыгай, АВ Артамонов, АА Бекарев, ВВ Жданов… - 2011 - elibrary.ru
В монографии описаны нанотехнологичные подходы к созданию лекарственных
средств и преимущества использования нанотехнологии электронно-лучевого синтеза …

Pharmacokinetic and-dynamic modelling of G-CSF derivatives in humans

M Scholz, S Schirm, M Wetzler, C Engel… - Theoretical Biology and …, 2012 - Springer
Background The human granulocyte colony-stimulating factor (G-CSF) is routinely applied to
support recovery of granulopoiesis during the course of cytotoxic chemotherapies. However …

Loss of the ubiquitin-conjugating enzyme UBE2W results in susceptibility to early postnatal lethality and defects in skin, immune, and Male reproductive systems

B Wang, SA Merillat, M Vincent, AK Huber… - Journal of Biological …, 2016 - ASBMB
UBE2W ubiquitinates N termini of proteins rather than internal lysine residues, showing a
preference for substrates with intrinsically disordered N termini. The in vivo functions of this …