G protein-gated inwardly rectifying potassium (GIRK) channels are regulators of neuronal
excitability in the brain. Knockout mice lacking GIRK channels display altered behavioral …

Adolescence is known for its high level of risk-taking, and neurobiological alterations during
this period may predispose to psychoactive drug initiation and progression into more severe …

Individuals suffering from substance-use disorders develop strong associations between the
drug's rewarding effects and environmental cues, creating powerful, enduring triggers for …

Different data suggest that microglia may participate in the drug addiction process as these
cells respond to neurochemical changes induced by the administration of these substances …

Leukocyte infiltration and persistence within peripheral nerves have been implicated in
chronic nociception pathogenesis in murine peripheral neuropathy models. Endoneurial …

The activity-regulated cytoskeleton-associated protein (Arc, also known as Arg3. 1), an
immediate early gene and synaptic regulator, is upregulated following a single cocaine …

Sensitization of motor activity is a behavioural test to evaluate the effects of
psychostimulants. Conditioned place preference (CPP) is an associative learning procedure …

Background Long-term cocaine exposure leads to dysregulation of the reward system and
initiates processes that ultimately weaken its rewarding effects. Here, we studied the …

Epigenetic mechanisms have been proposed to contribute to persistent aspects of addiction‐
related behaviors. One family of epigenetic molecules that may regulate maladaptive …

Substance abuse disorder is a chronic condition for which pharmacological treatment
options remain limited. L-type calcium channels (LTCC) have been implicated in drug …