The G protein-coupled oestrogen receptor GPER in health and disease: an update

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2023 - nature.com
Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

G protein–coupled estrogen receptor GPER: molecular pharmacology and therapeutic applications

JB Arterburn, ER Prossnitz - Annual review of pharmacology …, 2023 - annualreviews.org
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

Geraniol-mediated suppression of endoplasmic reticulum stress protects against cerebral ischemia–reperfusion injury via the PERK-ATF4-CHOP pathway

Y Wu, X Fan, S Chen, L Deng, L Jiang, S Yang… - International Journal of …, 2022 - mdpi.com
Endoplasmic reticulum (ER) stress plays an important role in cerebral ischemia–reperfusion
injury (CIRI). Geraniol has antioxidant, antibacterial, and anti-inflammatory activities. Studies …

[HTML][HTML] Epimedin B exerts neuroprotective effect against MPTP-induced mouse model of Parkinson's disease: GPER as a potential target

M Zhang, ZF Hu, XL Dong, WF Chen - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Mitochondrial dysfunction and oxidative stress play important roles in the
neuropathogenesis of Parkinson's disease (PD). Epimedin B, the second highest active …

[HTML][HTML] LncRNA ROR is involved in cerebral hypoxia/reoxygenation-induced injury in PC12 cells via regulating miR-135a-5p/ROCK1/2

H Chen, X Li - American Journal of Translational Research, 2019 - ncbi.nlm.nih.gov
Ischemic stroke is a common cerebrovascular disease with high morbidity, disability and
mortality. LncRNAs were involved in ischemia/reperfusion injury. The present study aims to …

[HTML][HTML] Exploring the physiological role of the G protein-coupled estrogen receptor (GPER) and its associations with human diseases

M Żabińska, K Wiśniewska, G Węgrzyn… - …, 2024 - Elsevier
Estrogen is a group of hormones that collaborate with the nervous system to impact the
overall well-being of all genders. It influences many processes, including those occurring in …

Neurosteroids and their receptors in ischemic stroke: from molecular mechanisms to therapeutic opportunities

Z Vahidinia, M Karimian, MT Joghataei - Pharmacological research, 2020 - Elsevier
Extensive progress has been made to understand the pathophysiology of stroke but it is still
a major cause of mortality and disability worldwide. There are few strategies for the …

Oxidative stress, apoptosis, and transcriptional responses in Acropora microphthalma under simulated diving activities

Y Zhang, RW Chen, X Liu, M Zhu, Z Li, A Wang… - Marine Pollution …, 2022 - Elsevier
This study simulated the effects of diving activities on the physiology, enzymatic, and
transcriptional responses of Acropora microphthalma. Touching had less impact on Fv/Fm …

GPER agonist G-1 disrupts tubulin dynamics and potentiates temozolomide to impair glioblastoma cell proliferation

A Hirtz, N Lebourdais, F Rech, Y Bailly, A Vaginay… - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most common brain tumor in adults, which is very aggressive,
with a very poor prognosis that affects men twice as much as women, suggesting that female …

17β-estradiol attenuates neuropathic pain caused by spared nerve injury by upregulating CIC-3 in the dorsal root ganglion of ovariectomized rats

ZZ Xu, QY Chen, SY Deng, M Zhang, CY Tan… - Frontiers in …, 2019 - frontiersin.org
17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain
prevalence, but the underlying mechanisms remain unclear. Here, we investigated whether …