Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

The liver is a central immunological organ. Liver resident macrophages, Kupffer cells (KC),
but also sinusoidal endothelial cells, dendritic cells (DC) and other immune cells are …

Liver fibrogenesis is a dynamic and highly integrated molecular, tissue and cellular process,
potentially reversible, that drives the progression of chronic liver diseases (CLD) towards …

The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key
role in host defense against viral infection and tumor transformation. Recent evidence from …

Chemokines are small chemotactic molecules that play key roles in physiological and
pathological conditions. Upon signaling via their specific receptors, chemokines regulate …

Introduction NK cells have been introduced as the main innate arm of immunity against
malignancies. Recent advances introduced new subsets of, and new effector molecules on …

NK cells are important antiviral effectors, highly enriched in the liver, with the potential to
regulate immunopathogenesis in persistent viral infections. Here we examined whether …

Background & Aims HIV/HCV co-infection is characterized by a faster progression to liver
fibrosis compared to HCV mono-infection. Epidemiologic studies found an association …