Autism is a severe developmental disorder of communication and reciprocal social
interaction with repetitive, odd behaviors (American Psychiatric Association, 1994). While …

We investigated how the neural cell adhesion molecule L1 mediates neurite outgrowth
through L1-L1 homophilic interactions. Wild-type L1 and L1 with mutations in the …

Bone remains one of the major sites, and most lethal host organs, for prostate cancer
metastasis. Prostate cell spread and establishment in bone depends on multiple reciprocal …

Williams Syndrome (WS,[MIM 194050]) is a disorder caused by a hemizygous deletion of 25–
30 genes on chromosome 7q11. 23. Several of these genes including those encoding …

A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion
molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at …

With the rapid progression in gene technologies, transgenic, targeted, and chemically
induced mutations in mice are continually created. The major goal of these studies is to …

Abstract Coffin–Lowry Syndrome (CLS) is an X-linked syndromic form of mental retardation
associated with skeletal abnormalities. It is caused by mutations of the Rsk2 gene, which …

The neural adhesion molecule L1, a member of the immunoglobulin superfamily of cell
recognition molecules, performs important functions in the developing and adult nervous …

Motility of nerve growth cones (GCs) is regulated by region-specific activities of cell
adhesion molecules (CAMs). CAM activities could be modified by their localization to …

Modulation of the sonic hedgehog (SHH) pathway is a crucial factor in cerebellar
morphogenesis. Stimulation of granule neuron progenitor (GNP) proliferation is a central …