Effective clinical methods for large bone defects are not yet available on account of the
complex intrinsic structure and mechanical characteristics of natural bone tissue. It remains …

Peptide-based hydrogels are widely studied and applied in bone repair because of their
good biocompatibility, biodegradability and designability. Peptide-based hydrogels can be …

Inspired by the hierarchical macro and microstructures widely found in nature, this study
proposes a novel hierarchical honeycomb design methodology. The aim is to overcome the …

Large bone defects remain an unsolved clinical challenge because of the lack of effective
vascularization in newly formed bone tissue. 3D bioprinting is a fabrication technology with …

Alloying and structural design provide flexibility to modulate performance of biodegradable
porous implants manufactured by laser powder bed fusion (L-PBF). Herein, bulk Zn-0.8 Li …

Postoperative anatomical reconstruction and prevention of local recurrence after tumor
resection are two vital clinical challenges in osteosarcoma treatment. A three-dimensional …

Bone fusion of defect broken ends is the basis of the functional reconstruction of critical
maxillofacial segmental bone defects. However, the currently available treatments do not …

Additively manufactured (AM) degradable porous metallic biomaterials offer unique
opportunities for satisfying the design requirements of an ideal bone substitute. Among the …

Titanium (Ti) and its alloys have been extensively explored for treating load-bearing bone
defects. However, high-stress shielding, weak osteogenic activity, and insufficient …

Stem cell based transplants effectively regenerate tissues; however, limitations such as
immune rejection and teratoma formation prevent their application. Extracellular vesicles …