Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Immunometabolism has emerged as a major mechanism central to adaptive and innate
immune regulation. From early observations that inflammatory cytokines were induced in …

NK cells are central to anti-tumor immunity and recently showed efficacy for treating
hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment …

Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune
responses to tumours and viral infection. However, in certain chronic diseases, including …

Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors
develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte …

While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …

Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …