Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …

Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key
negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we …

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector
function | Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death.
The immune-rich contexture of the HCC microenvironment makes this tumour an appealing …

Natural killer (NK) cells have crucial roles in tumor surveillance. We found that tumor-
infiltrating NK cells in human liver cancers had small, fragmented mitochondria in their …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Glioblastoma (GBM) is a highly aggressive primary brain tumour and is resistant to nearly all
available treatments, including natural killer (NK) cell immunotherapy. However, the factors …

The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical
models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have …

Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …