Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …

Rationale: Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype
and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers. Objectives: To …

Natural killer (NK) cells play critical roles in protection against hematological malignancies
but can acquire a dysfunctional state, which limits antitumor immunity. However, the …

Tumor microenvironment is a special environment for tumor survival, which is characterized
by hypoxia, acidity, nutrient deficiency, and immunosuppression. The environment consists …

The remarkable success of cancer immunotherapies has provided new hope to cancer
patients. Unfortunately, a significant proportion of patients remain unable to respond to …

Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

Tumour growth and dissemination is largely dependent on nutrient availability. It has
recently emerged that the tumour microenvironment is rich in a diverse array of lipids that …

NK cells play important roles in the innate immune responses against tumors. The effector
function of NK cells relies on the integration of activating and inhibitory signals. Emerging …

As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has
received increasing attention in recent years, and its safety and high efficiency have …