Natural killer (NK) cells are important early responders against viral infections. Changes in
metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell …

Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Determining divergent metabolic requirements of T cells, and the viruses and tumours they
fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA: cholesterol …

Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …

The pathophysiological roles of mast cells are still not fully understood, over 140 years since
their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct …

Obesity is accompanied by a systemic chronic low-grade inflammation as well as
dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an …

Breast cancer progression is highly dependent on the heterotypic interaction between tumor
cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes …

NK cells are capable of an array of functions that range widely from their classic anti-tumor
and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling …

Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling
molecules that poison surrounding cells, leading to various age-related diseases, including …