Clinical biology of the pituitary adenoma

S Melmed, UB Kaiser, MB Lopes, J Bertherat… - Endocrine …, 2022 - academic.oup.com
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement

S Petersenn, M Fleseriu, FF Casanueva… - Nature Reviews …, 2023 - nature.com
Abstract This Consensus Statement from an international, multidisciplinary workshop
sponsored by the Pituitary Society offers evidence-based graded consensus …

Real-life efficacy and predictors of response to immunotherapy in pituitary tumors: a cohort study

MD Ilie, C Villa, T Cuny, C Cortet, G Assie… - European journal of …, 2022 - academic.oup.com
Objective After temozolomide failure, no evidence-based treatment is available for pituitary
carcinomas (PCs) and aggressive pituitary tumors (APTs). To date, only 12 cases treated …

Immunotherapy in aggressive pituitary tumors and carcinomas: a systematic review

MD Ilie, A Vasiljevic, E Jouanneau… - Endocrine-related …, 2022 - erc.bioscientifica.com
Once temozolomide has failed, there is no recommended treatment option for pituitary
carcinomas and aggressive pituitary tumors. Immune-checkpoint inhibitors (ICIs) represent …

Prognostic factors for recurrence in pituitary adenomas: recent progress and future directions

L Lu, X Wan, Y Xu, J Chen, K Shu, T Lei - Diagnostics, 2022 - mdpi.com
Pituitary adenomas (PAs) are benign lesions; nonetheless, some PAs exhibit aggressive
behaviors, which lead to recurrence. The impact of pituitary dysfunction, invasion-related …

Real-life clinical impact of a five-tiered classification of pituitary tumors

N Sahakian, R Appay, N Resseguier… - European Journal of …, 2022 - academic.oup.com
Introduction Usually benign, pituitary tumors (PT) can be invasive and aggressive with a
propensity to progress and/or recur. Trouillas's clinicopathological classification attempts to …

Aggressive corticotroph tumors and carcinomas

H Lasolle, A Vasiljevic, E Jouanneau… - Journal of …, 2022 - Wiley Online Library
Pituitary tumors are generally benign, although in rare cases aggressive pituitary tumors
(APTs) and carcinomas present important diagnostic and therapeutic challenges and are …

Molecular genetic testing in the management of pituitary disease

EC Coopmans, M Korbonits - Clinical Endocrinology, 2022 - Wiley Online Library
Objective Most pituitary tumours occur sporadically without a genetically identifiable
germline abnormality, a small but increasing proportion present with a genetic defect that …

The Role of Activation of PI3K/AKT/mTOR and RAF/MEK/ERK Pathways in Aggressive Pituitary Adenomas—New Potential Therapeutic Approach—A Systematic …

A Derwich, M Sykutera, B Bromińska, B Rubiś… - International Journal of …, 2023 - mdpi.com
Pituitary tumors (PT) are mostly benign, although occasionally they demonstrate aggressive
behavior, invasion of surrounding tissues, rapid growth, resistance to conventional …

Immunotherapy in pituitary carcinomas and aggressive pituitary tumors

G Raverot, MD Ilie - Best Practice & Research Clinical Endocrinology & …, 2022 - Elsevier
After temozolomide failure, no evidence-based treatment option is currently available for
aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs). Moreover, once …