Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact
on morbidity and mortality. The pathophysiology driving the development of these conditions …

Doxorubicin (DOX) is an extremely effective and wide-spectrum anticancer drug, but its long-
term use can lead to heart failure, which presents a serious problem to millions of cancer …

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and age is by far
the greatest risk factor for developing CVD. Vascular dysfunction, including endothelial …

Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children,
and imposes significant morbidity and mortality in this population. The aggressive …

Introduction Anthracycline chemotherapeutic agents are widely used in the treatment of
hematological and solid tumors, working principally through DNA intercalation and …

Anthracyclines are chemotherapeutic agents widely used to treat a variety of cancers, and
these drugs have revolutionized our management of cancer patients. The dose‐dependent …

This study aimed to evaluate if Simvastatin can reduce, and/or prevent, Doxorubicin (Doxo)-
induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then …

Doxorubicin (Dox) is an effective anticancer molecule, but its clinical efficacy is limited by
strong cardiotoxic side effects. Lysosomal dysfunction has recently been proposed as a new …

Background Cardioprotective therapies represent an important avenue to reduce treatment-
limiting cardiotoxicities in patients receiving chemotherapy. However, the optimal duration …

There is insufficient evidence about the cardioprotective effects of statins against
chemotherapy-induced cardiomyopathy. The MEDLINE and EMBASE databases were …