[HTML][HTML] Risk factors of daunorubicine induced early cardiotoxicity in childhood acute lymphoblastic leukemia: A retrospective study

SM Samosir, IKA Utamayasa… - Asian Pacific Journal …, 2021 - ncbi.nlm.nih.gov
Background: Daunorubicine, a type of anthracycline, is a drug commonly used in cancer
chemotherapy that increases survival rate but consequently compromises with …

[HTML][HTML] The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials

AM Amin, Y Khlidj, M Abuelazm, AA Ibrahim… - Cardio-Oncology, 2024 - Springer
Background Cardiotoxicity is one of the most common adverse events of the chemotherapy.
Physical exercise was shown to be cardioprotective. We aim to estimate the efficacy and …

Anthracycline cardiotoxicity is exacerbated by global p38β genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss

SA George, A Kiss, KA Trampel… - American Journal …, 2023 - journals.physiology.org
Severe cardiotoxic effects limit the efficacy of doxorubicin (DOX) as a chemotherapeutic
agent. Activation of intracellular stress signaling networks, including p38 mitogen-activated …

[HTML][HTML] A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect

R Bjørnstad, IN Reiten, KS Knudsen, J Schjøtt… - International Journal of …, 2022 - Elsevier
Anthracyclines such as doxorubicin (Dox) are the preferred chemotherapeutics for several
cancers. However, Dox-induced cardiotoxicity limits its therapeutic potential. Liposomal …

[HTML][HTML] PKR-mediated phosphorylation of eIF2a and CHK1 is associated with doxorubicin-mediated apoptosis in HCC1143 triple-negative breast cancer cells

S Lee, HY Jee, YG Lee, JI Shin, YJ Jeon… - International Journal of …, 2022 - mdpi.com
Triple-negative breast cancer is more aggressive than other types of breast cancer. Protein
kinase R (PKR), which is activated by dsRNA, is known to play a role in doxorubicin …

Abnormal global longitudinal strain during anthracycline treatment predicts future cardiotoxicity in children

M Gunsaulus, T Alsaied, JM Tersak, E Friehling… - Pediatric …, 2023 - Springer
Global longitudinal strain (GLS) is a sensitive predictor of cardiotoxicity in adults with cancer.
However, the significance of abnormal GLS during childhood cancer treatment is less well …

[HTML][HTML] Transcriptome analysis of long noncoding RNAs reveals their potential roles in anthracycline-induced cardiotoxicity

N Nguyen, T Souza, J Kleinjans, D Jennen - Non-coding RNA Research, 2022 - Elsevier
Abstract Aims Anthracyclines (ANTs) are essential chemotherapeutic agents; however, their
adverse effects can lead to heart failure in cancer survivors. While long non-coding RNAs …

[HTML][HTML] Anthracycline toxicity

M Johnson, D Keyes - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
Anthracycline toxicity describes the toxic consequences of anthracycline-class medications.
Anthracyclines, such as doxorubicin and epirubicin, are potent chemotherapy agents …

Anthracycline chemotherapy, vascular dysfunction and cognitive impairment: burgeoning topics and future directions

GS Maurer, ZS Clayton - Future Cardiology, 2023 - Taylor & Francis
Anthracyclines, chemotherapeutic agents used to treat common forms of cancer, increase
cardiovascular (CV) complications, thereby necessitating research regarding interventions …

Left atrial strain in cardiac surveillance of bone marrow transplant patients with prior anthracycline exposure

P Emerson, T Deshmukh, L Stefani… - International Journal of …, 2022 - Elsevier
Background Bone marrow transplantation (BMT) has significantly improved survival rates in
various hematological malignancies. However, this has led to an increased prevalence of …