Disrupted striatal neuron inputs and outputs in Huntington's disease
A Reiner, YP Deng - CNS neuroscience & therapeutics, 2018 - Wiley Online Library
Huntington's disease (HD) is a hereditary progressive neurodegenerative disorder caused
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …
[HTML][HTML] Huntington's disease mouse models: Unraveling the pathology caused by CAG repeat expansion
J Kaye, T Reisine, S Finkbeiner - Faculty reviews, 2021 - ncbi.nlm.nih.gov
Huntington's disease (HD) is a neurodegenerative disease that results in motor and
cognitive dysfunction, leading to early death. HD is caused by an expansion of CAG repeats …
cognitive dysfunction, leading to early death. HD is caused by an expansion of CAG repeats …
[HTML][HTML] Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175
LB Menalled, AE Kudwa, S Miller, J Fitzpatrick… - PloS one, 2012 - journals.plos.org
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, cognitive and psychiatric manifestations. Since the mutation …
characterized by motor, cognitive and psychiatric manifestations. Since the mutation …
Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice
YP Deng, T Wong, C Bricker-Anthony, B Deng… - Neurobiology of …, 2013 - Elsevier
Motor slowing, forebrain white matter loss, and striatal shrinkage have been reported in
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …
The phosphodiesterase 10 positron emission tomography tracer,[18F] MNI-659, as a novel biomarker for early Huntington disease
DS Russell, O Barret, DL Jennings, JH Friedman… - JAMA …, 2014 - jamanetwork.com
Importance In Huntington disease (HD) striatal neuron loss precedes and predicts motor
signs or symptoms. Current imaging biomarkers lack adequate sensitivity for assessing the …
signs or symptoms. Current imaging biomarkers lack adequate sensitivity for assessing the …
Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse
Y Hu, V Chopra, R Chopra… - Proceedings of the …, 2011 - National Acad Sciences
Huntington disease (HD) is a progressive neurodegenerative disease that affects 30,000
individuals in North America. Treatments that slow its relentless course are not yet available …
individuals in North America. Treatments that slow its relentless course are not yet available …
Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging
DS Russell, DL Jennings, O Barret, GD Tamagnan… - Neurology, 2016 - AAN Enterprises
Objective: To evaluate whether striatal [18F] MNI-659 PET imaging of phosphodiesterase
10A (PDE10) serves as a sensitive and reliable biomarker of striatal neurodegeneration in a …
10A (PDE10) serves as a sensitive and reliable biomarker of striatal neurodegeneration in a …
Phenotype onset in Huntington's disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
NR Franich, MA Hickey, C Zhu… - Journal of …, 2019 - Wiley Online Library
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an
expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in …
expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in …
Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice
Y Deng, H Wang, M Joni, R Sekhri… - Journal of Comparative …, 2021 - Wiley Online Library
We used behavioral testing and morphological methods to detail the progression of basal
ganglia neuron type‐specific pathology and the deficits stemming from them in male …
ganglia neuron type‐specific pathology and the deficits stemming from them in male …
In vivo assessment and dosimetry of 2 novel PDE10A PET radiotracers in humans: 18F-MNI-659 and 18F-MNI-654
O Barret, D Thomae, A Tavares, D Alagille… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Phosphodiesterase (PDE) 10A is an enzyme involved in the regulation of cyclic adenosine
monophosphate and cyclic guanosine monophosphate and is highly expressed in medium …
monophosphate and cyclic guanosine monophosphate and is highly expressed in medium …