Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Macrophages are one of the most important cells in the innate immune system, they are
converted into two distinct subtypes with completely different molecular phenotypes and …

Macrophages are critical mediators of tissue homeostasis, with the function of tissue
development and repair, but also in defense against pathogens. Tumor-associated …

Children and adolescents with rhabdomyosarcoma (RMS) comprise a heterogeneous
population with variable overall survival rates ranging between approximately 6% and 100 …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

PURPOSE The VIT-0910 trial was conducted to evaluate efficacy and safety of the
vincristine-irinotecan combination with and without temozolomide (VIT and VI, respectively) …

Simple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal
muscle in children and young adults. It is responsible for 3% of all childhood malignant …

Triggered drug delivery strategies have been shown to enhance drug accumulation at target
diseased sites in comparison to administration of free drug. In particular, many studies have …

Relapsed rhabdomyosarcoma (RMS) represents a significant therapeutic challenge. Nearly
one-third of patients diagnosed with localized RMS and over two-thirds of patients with …