The application of endomorphins as clinical available analgesic drugs has been impeded by
their relatively poor receptor selectivity compared with alkaloid analgesics, rapid …

Spinal analgesic effects of endomorphin‐1 and endomorphin‐2 were studied during acute,
inflammatory, and neuropathic pain in rats chronically implanted with intrathecal cannulas …

The catabolism of the endomorphins was investigated in detail. The endomorphins were
degraded relatively slowly in the rat brain homogenate (t1/2 (endomorphin-1)= 4.94 min; t1/2 …

The μ-receptor is the primary mediator of the effects of morphine and the endogenous
opiates, endomorphin-1 and endomorphin-2. Here we demonstrate a dissociation of the …

Centrally acting plant opiates, such as morphine, are the most frequently used analgesics for
the relief of severe pain, even though their undesired side effects are serious limitation to …

Endomorphins (EMs) are endogenous selective μ-opioid receptor agonists. Their role in
inflammatory pain has not been fully elucidated. Here we examine peripheral …

Endomorphin-1 (Tyr-Pro-Trp-PheNH2) has been proposed as the most potent endogenous
ligand of the μ-opioid receptors. In this paper, we describe the synthesis of some …

The Tyr-MIF-1 family of small peptides has served a prototypic role in the introduction of
several novel concepts into the peptide field of research. MIF-1 (Pro-Leu-Gly-NH2) was the …

Opioid receptors and opioid peptides constitute the endogenous opioid system. The most
relevant function of the opioid system seems to be the inhibitory modulation of nociceptive …

The actions of opioid receptor agonists on the calcium channel currents (IBa) of acutely
dissociated periaqueductal grey (PAG) neurons from C57B16/J mice and mutant mice …