Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus

V Alur, V Raju, B Vastrad, C Vastrad… - Clinical Medicine …, 2023 - journals.sagepub.com
Background: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder. The
aim of the present investigation was to identify gene signature specific to T2DM. Methods …

[HTML][HTML] Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations

LT Tang, L Feng, HY Cao, R Shi, BB Luo… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND The global prevalence of type 2 diabetes mellitus (T2DM) is increasing.
T2DM is associated with alterations of the gut microbiota, which can be affected by age …

Analysis of key genes and pathways associated with the pathogenesis of Type 2 diabetes mellitus

V Alur, V Raju, B Vastrad, C Vastrad, S Kotturshetti - bioRxiv, 2021 - biorxiv.org
Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder which poses a
serious threat to human health. This investigation aimed to screen the candidate genes …

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

BM Vastrad, CM Vastrad - bioRxiv, 2023 - biorxiv.org
Schizophrenia is thought to be the most prevalent chronic psychiatric disorder. Numerous
proteins have been identified that are associated with the occurrence and development of …

Screening and identification of key biomarkers in diabetic kidney disease and its complications: Evidence from bioinformatics and next generation sequencing data …

B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Diabetic patients are prone to diabetic kidney disease (DKD), which may cause
cardiovascular damage, hypertension and obesity, and reduce quality of life. As a result, the …

Identification of biomarkers and pathways for focal segmental glomerulosclerosis using next generation sequencing data and bioinformatics analysis

B Vastrad, C Vastrad - bioRxiv, 2022 - biorxiv.org
Focal segmental glomerulosclerosis (FSGS) is a renal disease leading threat to human
health around the world. Here we aimed to explore novel molecular and potential …

Single Nucleotide Polymorphisms of NLRP12 Gene and Association with Psoriasis

J Li, Y Hui, Y Gao, Q Kong, H Liu, H Sang, F Liu - 2023 - researchsquare.com
Background NLRP12 has been authenticated as an important negative regulator in multiple
metabolic and inflammatory diseases. Psoriasis is an important inflammatory disease and …

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

M Giriyappagoudar, B Vastrad, R Horakeri, C Vastrad - bioRxiv, 2022 - biorxiv.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public
health threat globally. To discover key molecular changes in COVID-19 and its secondary …

[PDF][PDF] Exploring the mechanism of Pinggan Yishen granules in the treatment of hypertension and insomnia through network pharmacology and molecular docking

YD Fan, SQ Zhang, HF Zhao, ZY Fang - TMR Pharmacol Res, 2022 - tmrjournals.com
Background: Hypertension is closely related to insomnia. Pinggan Yishen (PGYS) Granule
is an effective compound medicine for treating hypertension and insomnia. In this study, we …

Bioinformatics analysis of differentially expressed genes in non alcoholic fatty liver disease using next generation sequencing data

B Vastrad, C Vastrad - bioRxiv, 2021 - biorxiv.org
Non alcoholic fatty liver disease (NAFLD) is the most common metabolic disease in humans,
affecting the majority of individuals. In the current investigation, we aim to identify potential …