Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Normy żywienia dla populacji Polski przez wiele lat były opracowywane przez ekspertów
Instytutu Żywności i Żywienia (IŻŻ). Również prace nad tym wydaniem początkowo były …

Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

Cells require one-carbon units for nucleotide synthesis, methylation and reductive
metabolism, and these pathways support the high proliferative rate of cancer cells. As such …

Our group recently discovered that certain dietary nutrients possessing a trimethylamine
(TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the …

Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite
of choline, contributes to the risk of cardiovascular diseases, but little is known for non …